Morais Research Group
Medicinal Inorganic Chemistry Lab
Embedded Files
Peer-Reviewed Articles
Peer-Reviewed Articles
2025
2025
42. Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands
B. Marques, D.M. Engracia, J.F. Machado, J.A.S. Coelho, F. Mendes, T.S. Morais*, Pharmaceuticals, 2025, 18, 97
DOI: 10.3390/ph18010097
2024
2024
41. Tailored metal-based catalysts: a new platform for targeted anti-cancer therapies
M.I.P.S. Leitão, T.S. Morais*, Journal of Medicinal Chemistry, 2024, 67, 19, 16967
DOI: 10.1021/acs.jmedchem.4c01680
40. Editorial: Recent Advances in the Development of Hybrid Drugs
T.S. Morais*, Pharmaceutics, 2024, 16(7), 889
DOI: 10.3390/pharmaceutics16070889
39. Dual FGFR-targeting and pH-activatable ruthenium-peptide conjugates for targeted therapy of breast cancer
J.F. Machado, M. Sá, I. Pires, M.T. da Silva, F. Marques, J.A.S. Coelho, F. Mendes, M.F.M. Piedade, M. Machuqueiro, M.A. Jiménez, M.H. Garcia,
J.D.G. Correia, T.S. Morais*, Dalton Transactions, 2024, 53, 7682.
DOI: 10.1039/D4DT00497C
38. Exploiting Co(III)-Cyclopentadienyl Complexes To Develop Anticancer Agents
J.F. Machado, S. Cordeiro, J.N. Duarte, P.J. Costa, P.J. Mendes, M.H. Garcia, P.V. Baptista, A.R. Fernandes, T.S. Morais*, Inorganic Chemistry, 2024, 63, 13,
5783.
2023
2023
37. Copper(I)-Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity
J.F. Machado, F. Marques, T. Pinheiro, M.J.V. Brito, G. Scalese, L. Pérez-Díaz, L. Otero, J.P.M. António, D. Gambino, T.S. Morais*, ChemMedChem, 2023, 18,
e2023000.
2022
2022
36. Editorial: Rational Drug Design of Metal Complexes for Cancer Therapy
T.S. Morais*, A.R. Fernandes, P.V. Baptista, D. Gambino, Frontiers in Chemistry, 2022.
DOI: 10.3389/fchem.2022.1035274
35. Design and anticancer properties of new water-soluble ruthenium-cyclopentadienyl complexes
T.S. Morais*, F. Marques, P.J.A. Madeira, M.P. Robalo, M.H. Garcia, Pharmaceuticals, 2022, 15, 862.
DOI: 10.3390/ph15070862
34. Broad spectrum functional activity of structurally related monoanionic Au(III) bis(dithiolene) complexes
L. Gal, A. Filatre-Furcate, O. Jeannin; T. Roisnel, V. Dorcet, D. Fontinha, D. Francisco, M. Prudêncio, M. Martins, C. Soeiro, S.A. Sousa, J.H.
Leitão, T.S. Morais, I. Bártolo, N. Taveira, J.F. Guerreiro, F. Marques, D.M. Lorcy, International Journal of Molecular Sciences, 2022, 23, 7146.
DOI: 10.3390/ijms23137146
33. Are smart delivery systems the solution to overcome the lack of selectivity of current metallodrugs in cancer therapy?
J.F. Machado, T.S. Morais*, Dalton Transactions, 2022, 51, 2593-2609.
DOI: 10.1039/D1DT04079K
2021
2021
32. Ultrasonication Improves Solid Phase Synthesis of Peptides Specific for Fibroblast Growth Factor Receptor and for the Protein-Protein
Interface RANK-TRAF6
R.D.M. Silva, J.F. Machado, K. Gonçalves, F.M. Lucas, S. Batista, R. Melo, T.S. Morais*, J.D.G. Correia, Molecules, 2021, 26(23), 7349.
DOI: 10.3390/molecules26237349
31. Gold(I) bis(1,2,3-Triazol-5-ylidene) Complexes as Promising Selective Anticancer Compounds
J.F. Schlagintweit, C.H.G. Jakob, N.L. Wilke, M. Ahrweiler, C. Frias, J. Frias, M. König, E-M.H. J. Esslinger, F. Marques, J.F. Machado, R.M. Reich, T.S. Morais,
J.D.G. Correia, A. Prokop, F.E. Kühn, Journal of Medicinal Chemistry, 2021, 64, 21, 15747.
DOI: 10.1021/acs.jmedchem.1c01021
30. Binding of RuCp complexes with human apo-transferrin: fluorescence spectroscopy and molecular docking methods
F.C. Santos, P.J. Costa, M.H. Garcia, T.S. Morais*, BioMetals, 2021, 34, 1029–1042.
DOI: 10.1007/s10534-021-00325-w
29. Emerging molecular receptors for the specific-target delivery of ruthenium and gold complexes into cancer cells
J.F. Machado, J.D.G. Correia, T.S. Morais*, Molecules, 2021, 26(11), 3153.
DOI: 10.3390/molecules26113153
28. Bioconjugate supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo
B. Woods, R.D.M. Silva, C. Schmidt, D. Wragg, M. Cavaco, V.F.C. Ferreira, L. Gano, T.S. Morais, F. Mendes, J.D.G. Correia, A. Casini, Bioconjugate Chemistry,
2021, 32(7), 1399–1408.
DOI: 10.1021/acs.bioconjchem.0c00659
27. Cu(I) complexes as new antiproliferative agents against sensitive and doxorubicin resistant colorectal cancer cells: Synthesis,
Characterization, and Mechanisms of Action
D. Sequeira, P. V. Baptista, R. Valente, M.F.M. Piedade, M.H. Garcia, T.S. Morais*, A.R. Fernandes*, Dalton Transations, 2021, 50, 1845-1865.
DOI: 10.1039/D0DT03566A
2020
2020
26. New copper(I) complexes selective for prostate cancer cells
J.F. Machado, D.A. Sequeira, F.M. Marques, M.F.M. Piedade, M.V. Brito, M.H. Garcia, A.R Fernandes, T.S. Morais*, “Dalton Transations, 2020, 49, 12273-
12286.
DOI: 10.1039/D0DT02157A
25. Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective antitumor, antimicrobial and antiplasmodial agents
D. Fontinha, S.A. Sousa, T.S. Morais, M. Prudêncio, J.H. Leitão, Y.L. Gal, D. Lorcy, M.M. Andrade, M.F.G. Velho, M. Almeida, D. Belo, J.F. Guerreiro, R.A.L.
Silva, T. Pinheiro, F. Marques, Metallomics, 2020, 12, 974-987.
DOI: 10.1039/D0MT00064G
24. Novel “ruthenium cyclopentadienyl”-peptide conjugate complexes against human FGFR(+) breast cancer
J.F. Machado, M. Machuqueiro, F.M. Marques, M.P.A. Robalo, M.F.M. Piedade, M.H. Garcia, J.D.G. Correia, T.S. Morais*, Dalton Transations, 2020, 49, 5974-
5987.
DOI: 10.1039/D0DT00955E
2019
2019
23. First heterobimetallic Cu(I)−dppf complexes designed for anticancer applications: synthesis, structural characterization and
cytotoxicity
C. Bravo, M.P.A. Robalo, F.M. Marques, A.R Fernandes, D.A. Sequeira, M.F.M. da Piedade, M.H. Garcia, M.V. Brito, T.S. Morais*, New Journal of Chemistry,
2019, 43, 12308-12317.
DOI: 10.1039/C9NJ02068C
22. Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools
L. Gano, T. Pinheiro, A.P. Matos, F. Tortosa, T.F. Jorge, M.S. Gonçalves, T.S. Morais, A. Valente, A.I. Tomaz, M.H. Garcia, F. Marques, Anti-cancer Agents in
Medicinal Chemistry, 2019, 19(10), 1262-1275.
2018
2018
21. Important cytotoxic and cytostatic effects of new Copper(I)-phosphane compounds with NN, NO and NS bidentate ligands
T.S. Morais*, Y. Jousseaume, M.F.M. Piedade, C. Roma-Rodrigues, A.R. Fernandes, F. Marques, M.J.V. Brito, M.H. Garcia, Dalton Transactions, 2018, 47, 7819-
7829.
DOI: 10.1039/C8DT01653D
2017
2017
20. New copper(I) and heteronuclear copper(I)–ruthenium(II) complexes: Synthesis, structural characterization and cytotoxicity
J. Lopes, D. Alves, T.S. Morais*, P.J. Costa, M.F.M. Piedade, F. Marques, M.J.V. Brito, M.H Garcia, Journal of Inorganic Biochemistry, 2017, 169, 68-78.
DOI: 10.1016/j.jinorgbio.2017.01.007
19. In vivo performance of a ruthenium cyclopentadienyl compound in an orthotopic triple negative breast cancer model
N. Mendes, F. Tortosa, A. Matos, F. Marques, T.S. Morais, A. Valente, A.I. Tomaz, F. Gartner, M.H. Garcia, AAnti-cancer Agents in Medicinal Chemistry, 2017,
17(1), 126 - 136.
2016
2016
18. Tracking antitumor metallodrugs: promising agents with the Ru(II)and Fe(II)cyclopentadienyl scaffolds
T.S. Morais, A. Valente, A.I. Tomaz, F. Marques, M.H. Garcia, Future Medicinal Chemistry, 2016, 8(5), 527-544.
DOI: 10.4155/fmc.16.7
2015
2015
17. Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic trypanosomatid
parasite
M. Fernández, E.R. Arce, C. Sarniguet, T.S. Morais, A.I. Tomaz, C.O. Azar, R. Figueroa, J.D. Maya, A. Medeiros, M. Comini, M.H. Garcia, L. Otero, D. Gambino,
Journal of Inorganic Biochemistry, 2015, 153, 306-314.
DOI: 10.1016/j.jinorgbio.2015.06.018
16. A new ruthenium cyclopentadienyl azole compound with activity on tumor cell lines and trypanosomatid parasites
E.R. Arce, C. Sarniguet, T.S. Morais, M. Vieites, A.I. Tomaz, A. Medeiros, M. Comini, J. Varela, H. Cerecetto, M. González, F. Marques, M.H. Garcia, L. Otero, D.
Gambino, Journal of Coordination Chemistry, 2015, 68, 2923-2937.
2014
2014
15. Anticancer activity of structurally related ruthenium(II) cyclopentadienyl complexes
L. Côrte-Real, F. Mendes, J. Coimbra, T.S. Morais, A. I. Tomaz, A. Valente, M.H. Garcia, I. Santos, M.P. Bicho, F Marques; Journal of Biological Inorganic
Chemistry, 2014, 19, 853-867.
DOI: 10.1007/s00775-014-1120-y
14. New Water-soluble Ruthenium(II) Cytotoxic Complex: Biological Activity and Cellular Distribution
T.S. Morais, F.C. Santos, T.F. Jorge, L. Côrte-Real, P.J.A. Madeira, F. Marques, M.P. Robalo, A. Matos, I. Santos, M.H. Garcia, Journal of Inorganic Biochemistry,
2014, 130, 1 - 14.
2013
2013
13. Exploring the effect of the ligand design on the interactions between [Ru(5-C5H5)(PPh3)(N,O)] [CF3SO3] complexes and Human Serum
Albumin
TS. Morais, F.C. Santos, L. Côrte-Real, M.H. Garcia, Journal of Inorganic Biochemistry, 2013, 129, 94 - 101.
DOI: 10.1016/ j.jinorgbio. 2013.09.008
12. Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands
A.C. Gonçalves, T.S. Morais, M.P. Robalo, F. Marques, F. Avecilla, C.P. Matos, I. Santos, A.I. Tomaz, M.H. Garcia, Journal of Inorganic Biochemistry, 2013, 129, 1
- 8.
DOI: 10.1016/j.jinorgbio. 2013.07.033
11. Synthesis, structural characterization and leishmanicidal activity evaluation of ferroncenyl N-hterocyclic compounds
S. Quintal, T.S. Morais, C.P. Matos, M.P. Robalo, M.F.M. Piedade, M.J.V. Brito, M.H. Garcia, M. Marques, C. Maia, L. Campino, J. Madureira, Journal of
Organometallic Chemistry, 2013, 745-746, 299-311.
DOI: 10.1016j/jorganchem.2013.07.044
10. Cellular Uptake Mechanisms of na Antitumor Ruthenium compound: The endossomal/Lysosomal System as a Target for Anticancer
Metal-Based Drugs
L. Côrte-Real, A.P. Matos, I. Alho, T.S. Morais, A.I. Tomaz, M.H. Garcia, I. Santos, M.P. Bicho, F. Marques, Microscopy and Microanalysis, 2013, 1-9.
DOI: 10.1017/S143192761300175X
9. Biological activity and cellular uptake of [Ru(5-C5H5)(PPh3)(Me2bpy)][CF3SO3]
T.S. Morais, F.C. Santos, L. Côrte-Real, F. Marques, M.P. Robalo, P.J.A. Madeira, M.H. Garcia, Journal of Inorganic Biochemistry, 2013, 122, 8-17.
2012
2012
8. [RuII(h5-C5H5)(bipy)(PPh3)]+ a promising large spectrum antitumor agent: cytotoxic activity and interaction with human sérum albumin
A.I. Tomaz, T. Jakush, T.S. Morais, F. Marques, R.F.M. de Almeida, F. Mendes, É.A. Enyedy, I. Santos, J.C. Pessoa, T. Kiss, M.H. Garcia, Journal of Inorganic
Biochemistry, 2012, 117, 261 – 269.
DOI: 10.1016/j.jinorgbio. 2012.06.016
7. Gas-phase behaviour of Ru(II) cyclopentadienyl-derived complexes with N coordinated ligands by electrospray ionization mass
spectrometry: fragmentation pathways and energetics
P.J.A. Madeira†, T.S. Morais†, T. Silva, P. Florindo, M.H. Garcia, Rapid Communications in Mass Spectrometry, 2012, 26, 1675-1686.
DOI: 10.1002/rcm.6276
6. Synthesis and structural characterization of new piano-stool ruthenium(II) complexes bearing 1-butylimidazole heteroaromatic ligand
T.S. Morais, M.H. Garcia, M.P. Robalo, M.F.M. Piedade, M.T. Duarte, M.J.V. Brito, P.J A. Madeira, Journal of Organometallic Chemistry, 2012, 712, 112- 122.
DOI: 10.1016/j.jorganchem.2012.04.024
5. Synthesis of organometallic ruthenium(II) complexes with strong activity against several human cancer cell lines
T.S. Morais, T.J.L. Silva, F. Marques, M.P. Robalo, F. Avecilla, P.J.A. Madeira, P.J.G. Mendes, I. Santos, M.H. Garcia, Journal of Inorganic Biochemistry, 2012,
114, 65-74.
2011
2011
4. DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic
ligands
M.H. Garcia, T.S. Morais, A. Valente, M.P. Robalo, M. Font-Bardia, T. Calvet, J. Lorenzo, F.X. Avilés, Journal of Inorganic Biochemistry, 2011, 105, 241-249.
2010
2010
3. New Ruthenium(II) Mixed Metallocene derived complexes: Synthesis, Characterization by X-ray Diffraction Studies and Evaluation on
DNA interaction by Atomic Force Microcopy
M.H. Garcia, A. Valente, P. Florindo, T.S. Morais, M.F.M. Piedade, M.T. Duarte, V. Moreno, Inorganica Chimica Acta, 2010, 363, 3765- 3775.
DOI: 10.1016/j.ica.2010.05.034
2. Studies of the Antiproliferative Activity of Ruthenium(II) Cyclopentadienyl derived Complexes with Nitrogen Coordinated Ligands
V. Moreno, J. Lorenzo, F.X. Avilés, M.H. Garcia, J. Ribeiro, T.S. Morais, P. Florindo, Bioinorganic Chemistry and Applications, 2010, article ID 936834.
DOI: 10.1155/2010/396834
2009
2009
1. Inhibition of Cancer Cell Growth by Ruthenium(II) Cyclopentadienyl derivative Complexes with Heteroaromatic Ligands
M.H. Garcia, T.S. Morais, P. Florindo, M.F.M. Piedade, V. Moreno, C. Ciudad, V. Noe, Journal of Inorganic Biochemistry, 2009, 103, 354-361.
Page updated
Google Sites
Report abuse